Enzymatic ω-Oxidation
نویسندگان
چکیده
منابع مشابه
Enzymatic synthesis of chiral γ-amino acids using ω-transaminase.
In this study, we successfully synthesized enantiomerically pure (R)- and (S)-γ-amino acids (>99% ee) using ω-transaminase (ω-TA) through kinetic resolution and asymmetric synthesis respectively. The present study demonstrates the high potentiality of ω-TA reaction for the production of chiral γ-amino acids.
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Mitochondria of all animal tissues, so far investigated, contain an enzyme system which catalyzes the oxidation of mesoand (-)-tartrate. Certain properties of this enzyme system, such as its extraction and coensyme requirements as well as the isolation of oxidation products of tartrate, were described in a previous publication (1). The reconstruction of Reactions’ 1 to 3 was based on the chemic...
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4Winge, 0., and Roberts, C., Comp. Rend. Trav. Lab., Carlsb., Ser. Physiol., 24, 263-315 (1948). 5 Ryan, F. J., and Schneider, L. K., Genetics, 34, 72-91 (1949). 6 Luria, S. E., and Delbruck, M., Ibid., 28, 491-511 (1943). 7Mundkur, B., and Lindegren, C. C., Am. J. Botany, 36, 722-727 (1949). 8 Lea, D. E., and Coulson, C. A., J. Genetics, 49, 264-285 (1949). 9Spiegelman, S., Cold Spring Harbor ...
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The author focuses on the biological significance of ω-oxidation of fatty acids. Early studies revealed that there is a subsidiary pathway for β-oxidation of fatty acids when β-oxidation is blocked. Many studies demonstrated that the ω-oxidation serves to provide succinyl-CoA for the citric acid cycle and for gluconeogenesis under conditions of starvation and diabetes. Acylglucosylceramides whi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1970
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62932-1